Mechanobiology of nuclear import of transcription factors modelled within a bioengineered stem cell niche (NICHOID)

Polimi role:
Coordinator

Project website

Scientific coordinator:
Manuela Raimondi

The general goal of the project NICHOID is to control the function of stem cells when proliferating in vitro. Our aim is to fabricate miniaturized containers, so-called nichoids, to cultivate these cells in vitro. The nichoids are fabricated by polymerizing a resin using a pulsed laser beam. This fabrication technique allows to control their architecture down to the nanometer scale. The project is thus a frontier research in the field of nano-fabrication for biology, and gathers a team with knowledge in engineering, physics and biology. The stem cells cultivated in the nichoids will be employed as a drug to cure pathologies such as heart infarcts, spinal cord injury, inflammatory conditions such as arthritis and Crohn’s desease, and neurodegenerative conditions such as Parkinson’s disease.

Program: Horizon 2020

Subprogram: Pillar I - Excellent Science

Call: ERC-2014-COG

Topic: ERC-CoG-2014: ERC Consolidator Grant

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