Gene delivery carrier
Data di pubblicazione
Data di priorità
PCT, EP, US
Politecnico di Milano, MIT
Department of Chemistry Materials and Chemical Engineering
Moscatelli Davide, Capasso Palmiero Umberto, Anderson Daniel, Kaczmarek James
Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (β-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.