Gene delivery carrier
Data di pubblicazione
08-11-2021
Codice
CH.17.102.A
Stato
Disponibile
Data di prioritĂ
03-11-2017
Fase
PCT, EP, US
Titolare
Politecnico di Milano, MIT
Dipartimento
Department of Chemistry Materials and Chemical Engineering
Autori
Moscatelli Davide, Capasso Palmiero Umberto, Anderson Daniel, Kaczmarek James
Descrizione
Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (β-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.
Contatto
licensing.tto@polimi.it
