Anti-thyroid hormone (T4) recombinant antibody or antigen binding fragment

Data di pubblicazione

08-11-2021

Codice

CH.18.082.A

Stato

Disponibile

Data di priorità

15-08-2018

Fase

Nazionale (domanda nazionale Finlandese), regionale (EP), internazionale (PCT), Fasi Nazionali (Cina, US)

Titolare

Politecnico di Milano, VTT Technical Research Centre of Finland Ltd

Dipartimento

DIPARTIMENTO DI CHIMICA, MATERIALI E INGEGNERIA CHIMICA "GIULIO NATTA"

Autori

METRANGOLO PIERANGELO, NEVANEN TARJA, AROLA HENRI, TULLILA ANTTI, ROUVINEN JUHA, PARKKINEN TARJA

Descrizione

The present invention relates to the fields of antibodies, antigen binding fragments and immunodiagnostics. Specifically, the invention relates to a recombinant anti- body or antigen binding fragment for binding thyroid hormone T4 (thyroxine) and halogenated bisphenol A. Also, the present invention relates to an isolated nucleic acid molecule comprising a nucleotide sequence that encodes the recombinant antibody or antigen binding fragment of the present invention, as well as an ex- pression vector and host cell comprising the nucleic acid molecule of the present invention. Still, the present invention relates to a method of producing a recombi- nant antibody or antigen binding fragment for binding T4 thyroid hormone and hal- ogenated bisphenol A, a test kit and an immunoassay comprising the recombinant antibody or antigen binding fragment of the present invention, and a method for determining T4 thyroid hormone and/or halogenated bisphenol A levels in a sam- ple of a subject. Still further, the present invention relates to a method of treating a sample, e.g. an immunoaffinity-based sample preparation method for enrich- ment of the halogenated bisphenol A from a sample.

Contatto

licensing.tto@polimi.it