Gene delivery carrier

Data di pubblicazione

08-11-2021

Codice

CH.17.102.A

Stato

Disponibile

Data di priorità

03-11-2017

Fase

PCT, EP, US

Titolare

Politecnico di Milano, MIT

Dipartimento

DIPARTIMENTO DI CHIMICA, MATERIALI E INGEGNERIA CHIMICA "GIULIO NATTA"

Autori

Moscatelli Davide, Capasso Palmiero Umberto, Anderson Daniel, Kaczmarek James

Descrizione

Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize poly (β-amino ester) (PBAE) polymers, which are synthesized via Michael addition reactions of diacrylates and amines disclosed herein. Various embodiments utilize lactones and lactone derivatives to generate the diacrylate compounds. The PBAE polymers are shown to be effective biodegradable carriers for the delivery of an agent such as an organic molecule, inorganic molecule, nucleic acid, protein, peptide, polynucleotide, targeting agent, an isotopically labeled chemical compound, vaccine, or an immunological agent.

Contatto

licensing.tto@polimi.it

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