Non-viral vectors

Data di pubblicazione

23-06-2022

Codice

CH.21.130.A

Descrizione

Dendrimers are highly branched synthetic macromolecules with repetitive structures. These are characterized by a central core, layers of repeating units, and active end groups with surface charges. Fluorinated amphiphilic dendrimeric structures are capable of assembling into supramolecular systems of different size and shape. The structure comprises a hydrophilic portion based on polyester moieties. The subject of the following invention is supramolecular complexes that comprise at least one dendrimeric structure, one or more nucleic acids, and a pharmaceutically acceptable vector.

The structures of the dendrimers allow to make available a multiplicity of equivalent fluorine atoms (27 19F atoms), which allows to trace their localization when administered in an organism.

Campo di applicazione

<p> <ul> <li> Nanomedicine </li> </ul> <ul> <li> Gene therapy. </li> </ul> <ul> <li> Treatment of neurodegenerative neurological diseases. </li> </ul> </p>

Vantaggi

<p> <ul> <li> The dendrimeric structures make it possible to have available a multiplicity of magnetically equivalent fluorine atoms, which allow the use of magnetic resonance imaging. </li> </ul> <ul> <li> The presence of four ethereal bonds in the nucleus accelerates the degradation of the molecule in the environment. </li> </ul> <ul> <li> Superior transfection capacity and reduced cytotoxicity compared to non-viral lipid vectors. </li> </ul> </p>

Contatto

licensing.tto@polimi.it