THE MICELI (MICrofluidic, ELectronic, Impedance): Point of Care Microfluidic Chip for Real-Time Platelet Aggregation Measurement)

Data di pubblicazione






Data di priorità





Politecnico di Milano, Arizona Board of Regents on Behalf of the University of Arizona


Department of Electronics, Information and Bioengineering


Marco Rasponi, Cesare Luigi Redaelli Alberto, Marvin J. Slepian, Annalisa Dimasi, Andrea Santoleri


Thrombosis or “clot formation” is a basic pathologic process involved in many diseases including heart disease, stroke, and peripheral artery disease. The process of blood clotting is triggered by platelets activation, and their subsequent aggregation leads to progressive clot formation, vessel occlusion, tissue ischemia, infarction and ultimately death.

The MICELI is a simple, inexpensive, effective, reliable, compact device to assess platelet aggregation mechanisms (both its onset, progression and degree of severity) to guide and provide warning signs of disease progression and response to antiplatelet (drug) therapy. Such device could be used both at the patient bedside, and in the laboratory.

The MICELI microfluidic chip prototype is composed by three bonded layers of Polydimethylsiloxane (PDMS), embedding i) a central chamber ii) two micro-channels for the insertion of the aggregation agonists and iii) two silver electrodes for measurement of impedance variation as a function of the platelet aggregation dynamics.

Campo di applicazione

<p> The use of this technology is very important to prevent and monitor thrombotic phenomena and by consequence, heart diseases due to vessels clotting and various pathologies related to platelet activation. As this is a crucial sector in hospitals and medical care administration, the target is the customer segments of hospital laboratories as well as specialists in the blood platelet treatment arena. Platelet aggregation diagnostics is a type of examination that can be of vital importance in every pre-surgical field, as surgeons within hospitals, clinics and private practice would benefit from this new technology. </p> <p> Another important market area in which MICELI could be useful is research. </p>


<p> The devices and techniques nowadays used to measure platelets aggregation have the issue to be very expensive (because of purchase and maintenance), not so easy to use and not portable considering the big dimensions of the machines. THE MICELI is a very smart device that is perfectly portable and movable, being usable also in outdoor environment or in difficult conditions like developing country, and is a less expensive alternative, since the limited cost of the impedance analyzer of the MICELI since allows for a backup unit in case of rupture. </p>

Stadio di sviluppo

Working prototype