THE MICELI (MICrofluidic, ELectronic, Impedance): Point of Care Microfluidic Chip for Real-Time Platelet Aggregation Measurement)
Data di pubblicazione20-10-2021
Data di priorità23-06-2017
FaseUS , PCT
TitolarePolitecnico di Milano, Arizona Board of Regents on Behalf of the University of Arizona
DipartimentoDepartment of Electronics, Information and Bioengineering
AutoriMarco Rasponi, Cesare Luigi Redaelli Alberto, Marvin J. Slepian, Annalisa Dimasi, Andrea Santoleri
Thrombosis or “clot formation” is a basic pathologic process involved in many diseases including heart disease, stroke, and peripheral artery disease. The process of blood clotting is triggered by platelets activation, and their subsequent aggregation leads to progressive clot formation, vessel occlusion, tissue ischemia, infarction and ultimately death.
The MICELI is a simple, inexpensive, effective, reliable, compact device to assess platelet aggregation mechanisms (both its onset, progression and degree of severity) to guide and provide warning signs of disease progression and response to antiplatelet (drug) therapy. Such device could be used both at the patient bedside, and in the laboratory.
The MICELI microfluidic chip prototype is composed by three bonded layers of Polydimethylsiloxane (PDMS), embedding i) a central chamber ii) two micro-channels for the insertion of the aggregation agonists and iii) two silver electrodes for measurement of impedance variation as a function of the platelet aggregation dynamics.