Polyester-based excipients to formulate lipophilic drugs into nanoparticles and a method for producing said nanoparticles
Data di pubblicazione
Data di priorità
Politecnico di Milano
Department of Chemistry Materials and Chemical Engineering
Davide Moscatelli, Umberto Capasso Palmiero, Massimo Morbidelli (PoliMi), Maurizio D'Incalci (Istituto Mario Negri)
The invention consists in a new class of materials biocompatible and biodegradable for the transport of oligonucleotides based on PCLs (PolyCraptoLactones) diacrylates, and their synthesis method. These materials can transports oligonucleotides by the adoption of a living polymerization (a ring opening polymerization) and the Michael addition polymerization that permits to obtain poly-b-amino esters, that are more biocompatible than the PBAEs produced by bisphenol A dicarylate.
Campo di applicazione
Since the invention is a carrier of exogenous oligonucleotides, in other words a drug deliver, the main application is related to the pharmaceutics word for cancer immunotherapy, apoptosis-associated diseases, vaccines and genomic engineering, amongst others.
The main advantage of the poly-b-amino esters as mRNA carriers is related to the simplicity of synthesis, transfection efficiency and degradability. But differently from the PBAEs that derives from bisphenol A diacrylate (high transfer efficient mRNA transporter), that degrades into butanediol (a psychoactive drug) and into bisphenol A (potentially toxic) that are considered as dangerous compounds, our new class of diacrylates is more safe and biocompatible.