Insights on a mechanism to stop COVID-19 replication

Study of the Politecnico di Milano published in the New Journal of Chemistry

A study conducted by a group of researchers from the Politecnico di Milano was published in New Journal of Chemistry; they were able to establish, after analyzing more than 10,000, that a compound called EBSELEN is the most effective inhibitor of SARS-CoV-2 virus replication mechanism.

Two important aspects of the propagation of a virus are its ability to enter the host's cells, that is, to infect the host, and then to replicate in infected cells.

As for SARS-CoV-2, the Mpro protein plays an important role in the replication and transcription of the virus. Mpro therefore represents a particularly promising target for blocking the virus itself because a compound that inhibits Mpro blocks the virus; The peculiarity of EBSELEN is that it has proved to be the most powerful inhibitor of Mpro.

"We have identified that the selenium atom of EBSELEN strongly interacts with some groups typically present in proteins via the chalcogen bond, a weak bonding that has been studied for years in our laboratories; this binding may contribute to the inhibition of the virus replication. This represents an important step forward in the fight against COVID-19." Says Prof. Giuseppe Resnati of the Department of Chemistry, Materials and Chemical Engineering "Giulio Natta" of the Politecnico di Milano.

The article: